| Pair Name | Tangeretin, Metformin | ||
| Phytochemical Name | Tangeretin (PubChem CID: 68077 ) | ||
| Anticancer drug Name | Metformin (PubChem CID: 4091 ) | ||
| Structure of Phytochemical |
|
Download
2D
MOL
3D
MOL
|
|
| Structure of Anticancer Drug |
|
Download
2D
MOL
3D
MOL
|
|
| Pair Name | Tangeretin, Metformin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->ROS accumulation | |||
| Gene Regulation | Down-regulation | Phosphorylation | ABCB1 | hsa5243 |
| Down-regulation | Phosphorylation | ABCC1 | hsa4363 | |
| Down-regulation | Phosphorylation | AKT1 | hsa207 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | CASP7 | hsa840 | |
| Down-regulation | Expression | CDK2 | hsa1017 | |
| Down-regulation | Expression | CDK4 | hsa1019 | |
| Down-regulation | Phosphorylation | MAPK1 | hsa5594 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Up-regulation | Phosphorylation | PRKAA1 | hsa5562 | |
| Up-regulation | Activity | ROS1 | hsa6098 | |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 | |
| Result | The current work underscores the importance of metformin as an ERMA in tackling breast cancer and as a novel approach to boost its anticancer activity via a synergistic combination with tangeretin. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Tangeretin boosts the anticancer activity of metformin in breast cancer cells via curbing the energy production. Phytomedicine. 2021 Mar;83:153470. doi: 10.1016/j.phymed.2021.153470. | Click |
